Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma

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Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma

ETHNOPHARMACOLOGICAL RELEVANCE Dapivirine is one of reverse transcriptase inhibitors (RTIs). It is the prototype of diarylpyrimidines (DAPY), formerly known as TMC120 or DAPY R147681 (IUPAC name: 4- [[4-(2, 4, 6-trimethylphenyl) amino]-2-pyrimidinyl] amino]-benzonitrile; CAS no.244767-67-7). AIM The purpose of this study is to investigate the antitumor activity of dapivirine, one of the RTIs,...

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ژورنال

عنوان ژورنال: Journal of Cancer

سال: 2018

ISSN: 1837-9664

DOI: 10.7150/jca.21965